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Recharge and increase in hardness of GIC with CPP-ACP/F
Peiyan Shen1, Ilya Zalizniak1, Joseph E A Palamara1
1Oral Health Cooperative Research Centre, Melbourne Dental School, Bio21 Institute, The University of Melbourne, 720 Swanston Street, Victoria 3010, Australia.
Summary
Recharging glass ionomer cements (GIC) with casein phosphopeptide-amorphous calcium phosphate with fluoride (CPP-ACP/F) paste significantly boosted ion release and surface hardness. This CPP-ACP/F application enhances GIC resistance to acid degradation and improves caries control potential.
Area of Science:
- Dental Materials Science
- Biomaterials Engineering
- Caries Research
Background:
- Glass ionomer cements (GIC) are widely used restorative materials.
- GIC Fuji-Triage and Fuji-Triage-EP are formulations containing CPP-ACP/F.
- Assessing the impact of recharging these GICs with CPP-ACP/F is crucial for understanding their long-term performance.
Purpose of the Study:
- To evaluate the effect of recharging with CPP-ACP/F paste on ion release and surface hardness of GIC Fuji-Triage and Fuji-Triage-EP.
- To determine the distribution of CPP-ACP within Fuji-Triage-EP.
- To assess the acid resistance and potential for caries control of these GICs after recharging.
Main Methods:
- CPP-ACP distribution in Fuji-Triage-EP was confirmed using immunofluorescence.
- GIC blocks were exposed to lactic acid to simulate an acidic oral environment.
- Ion levels (calcium, phosphate, fluoride) and Vickers surface hardness were measured after treatment with CPP-ACP/F paste, placebo, or distilled water.
Main Results:
- CPP-ACP was found to be distributed throughout Fuji-Triage-EP.
- Treatment with CPP-ACP/F paste significantly increased calcium, inorganic phosphate, and fluoride ion release in both GIC types (p<0.001).
- Both GIC types exhibited enhanced surface hardness (acid resistance) after CPP-ACP/F treatment, with Fuji-Triage-EP showing superior performance compared to Fuji-Triage.
Conclusions:
- Topical application of CPP-ACP/F paste effectively recharges GIC Fuji-Triage and Fuji-Triage-EP.
- Recharging enhances ion release and surface hardness, improving acid resistance and potential for caries management.
- These findings suggest CPP-ACP/F recharging can improve the durability and therapeutic benefits of specific GIC formulations.
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