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Circular RNAs in liver diseases: Mechanisms and therapeutic targets

Li-Yun Fu1, Shu-Wei Wang2, Meng-Yuan Hu2

  • 1Department of Infection and Hepatology, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo 315010, China; Ningbo Institute of Life and Health Industry, University of Chinese Academy of Science, Ningbo 315010, China; Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province, Ningbo 315010, China; Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo 315211, China.

Life Sciences
|November 4, 2020
PubMed

Insights

Circular RNAs (circRNAs), stable molecules with unique loops, are linked to various liver diseases. Research highlights their role in disease progression and potential as diagnostic markers and therapeutic targets.

Area of Science:

  • Molecular Biology
  • Genetics
  • Hepatology

Background:

  • Circular RNAs (circRNAs) are covalently closed RNA molecules derived from precursor mRNA.
  • They exhibit high stability, abundance, and tissue-specific expression patterns.
  • Emerging evidence implicates circRNAs in the pathogenesis of diverse liver diseases.

Purpose of the Study:

  • To review the current research on the role of circRNAs in liver diseases.
  • To explore the diagnostic and prognostic potential of circRNAs.
  • To discuss the therapeutic implications of circRNAs in liver disease treatment.

Main Methods:

  • Literature review of studies investigating circRNAs in liver diseases.
  • Analysis of circRNA expression patterns and functional roles.
  • Evaluation of circRNAs as biomarkers and therapeutic targets.

Main Results:

  • CircRNAs are implicated in metabolic-associated fatty liver disease, hepatitis, liver cirrhosis, and hepatocellular carcinoma.
  • These molecules play significant roles in the progression of liver pathologies.
  • CircRNAs demonstrate potential as diagnostic and prognostic indicators.

Conclusions:

  • Circular RNAs are crucial players in liver disease development and progression.
  • CircRNAs hold promise as valuable biomarkers for liver disease diagnosis and prognosis.
  • Targeting circRNAs may offer novel therapeutic strategies for liver diseases.
Keywords:
Circular RNAHepatitisHepatocellular carcinomaLiver cirrhosisMetabolic-associated fatty liver disease

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