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Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets
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Recent advances in light-induced cell sheet technology.

Zhiwei Jiang1, Danji Zhu1, Ke Yu1

  • 1The Affiliated Stomatology Hospital, Zhejiang University School of Medicine, Hangzhou 310006, Zhejiang, China; Key Laboratory of Oral Biomedical Research of Zhejiang Province, Zhejiang University School of Stomatology, Hangzhou 310006, Zhejiang, China.

Acta Biomaterialia
|November 4, 2020
PubMed
Summary
This summary is machine-generated.

Light-based stimuli offer a novel method for detaching cell sheets, crucial for tissue regeneration and cell therapy. Further research is needed to establish safety standards and optimize light parameters for effective cell sheet fabrication.

Keywords:
Cell detachmentCell sheetLight-inducedMaterial surfaceTissue engineering

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Cell Biology

Background:

  • Cell sheet technology is a promising approach for tissue regeneration and cell therapy.
  • Various stimuli, including light, can be used to harvest complete cell sheets.
  • Current light-based methods require careful control and lack established safety standards.

Purpose of the Study:

  • To review the application of light stimuli for cell sheet fabrication.
  • To discuss the mechanisms underlying light-induced cell sheet detachment.
  • To identify limitations and future directions in light-based cell sheet technology.

Main Methods:

  • Review of existing literature on light-stimulated cell sheet detachment.
  • Analysis of different light wavelengths (UV, visible, NIR) and their effects.
  • Discussion of changes in surface properties and adhesive proteins.

Main Results:

  • Light illumination alters surface properties (wettability, potential, water content).
  • These changes induce conformational alterations in adhesive proteins/collagens, leading to cell sheet detachment.
  • Different light wavelengths can be employed for cell sheet fabrication.

Conclusions:

  • Light stimuli provide a viable method for cell sheet harvesting.
  • Further research is necessary to develop standardized, safe, and efficient light-based protocols.
  • Future work should focus on novel materials for rapid cell sheet culturing and release.