Total motorized spiral enteroscopy: first prospective clinical feasibility trial

Area of Science:

• Gastroenterology
• Endoscopy
• Medical Devices

Background:

• Motorized spiral enteroscopy (MSE) is a novel technique for antegrade enteroscopy.
• Previous studies indicated MSE is safe and effective for antegrade procedures.
• The efficacy and safety of MSE for complete small bowel visualization remained to be determined.

Purpose of the Study:

• To prospectively evaluate the efficacy and safety of MSE for complete small bowel visualization.
• To determine the total enteroscopy rate (TER) using MSE.
• To assess diagnostic yield, procedural success, and adverse events (AEs) associated with MSE.

Main Methods:

• A prospective, observational, bicentric trial was conducted.
• Patients underwent antegrade MSE, with a retrograde approach if needed.
• Primary endpoint was TER; secondary endpoints included diagnostic yield, procedural success, DMI, and AEs.

Main Results:

• Technical success for antegrade and retrograde MSE was 100%.
• Overall TER was 70% (16.6% antegrade alone, 53.4% bidirectional).
• High diagnostic (80%) and therapeutic (86.7%) yields were observed with a low AE rate (16.7%).

Conclusions:

• Complete enteroscopy is feasible with MSE, achieving high success rates and short procedural durations.
• MSE, used antegrade or bidirectionally, is a safe and effective method for small bowel examination.
• Further multicenter studies with control groups are warranted to validate these findings.