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Myeloid transformation by MLL-ENL depends strictly on C/EBP

Radoslaw Wesolowski1, Elisabeth Kowenz-Leutz1, Karin Zimmermann1

  • 1Max Delbrück Center for Molecular Medicine, Berlin, Germany.

Life Science Alliance
|November 4, 2020
PubMed
Summary

MLL-ENL infant leukemia cells require C/EBP transcription factors for transformation. Deleting Cebpa and Cebpb severely impaired leukemia cell growth, highlighting C/EBP dependency in MLL-driven oncogenesis.

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