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Updated: Dec 2, 2025

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
Published on: June 13, 2014
A New Generation of "Magic Bullets" for Molecular Targeting of Cancer
Jacek Capala1, Charles A Kunos2
1Division of Cancer Therapy and Diagnosis, NCI, NIH, Bethesda, Maryland. capalaj@mail.nih.gov.
Abstract:
A two-step molecular targeting approach involving a self-assembling and disassembling (SADA) bispecific antibody platform and DOTA-radioconjugates allows tumor-specific delivery of diagnostic and therapeutic payloads. Low immunogenicity and the modular nature of SADA allow its optimization to safely and repeatedly deliver a variety of payloads to tumors expressing diverse tumor-specific antigens.See related article by Santich et al., p. 532.
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