Related Experiment Video
Updated: Dec 2, 2025
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Evaluation of Blood-based Biomarkers for Prediction of Response in Carboplatin-treated Metastatic
Jennifer Moritz1, Thomas Bauernhofer1, Sebastian Mannweiler2
1Division of Oncology, Department of Internal Medicine, Medical University of Graz (MUG), Graz, Austria.
Background/Aim:
Carboplatin-containing treatment regimens demonstrate moderate efficacy in metastatic castration-resistant prostate cancer (mCRPC). In this study, we retrospectively analyzed the efficacy of carboplatin in relation to blood-based parameters.
Patients And Methods:
A retrospective chart review was performed for 20 patients with mCRPC who received carboplatin in a single center.
Results:
Median overall survival was 3.8 months (95%CI=1.5-7.1), median progression-free survival was 1.7 months. We observed two partial remissions (PR, 10%), four stable diseases (SD, 20%) and 14 disease progressions (PD, 70%), resulting in a clinical benefit rate of 30%. A doubling of NSE (neurone specific enolase) values was associated with a 19% absolute higher response rate (95%CI=14-23, p=0.027). All other laboratory parameters failed as predictive markers of response to carboplatin. In univariate Cox regression analysis, only NSE was significantly associated with impaired PFS (HR=0.7, 95%CI=0.56-0.96, p=0.030).
Conclusion:
Carboplatin showed moderate efficacy against mCRPC in this unselected population of patients and NSE levels may help to predict the success of this treatment.
