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Related Concept Videos

Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Bone Remodeling01:40

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Related Experiment Video

Updated: Dec 2, 2025

Longitudinal Evaluation of Mouse Hind Limb Bone Loss After Spinal Cord Injury using Novel, in vivo, Methodology
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CHANGES IN BONE MINERAL DENSITY AFTER TOTAL KNEE ARTHROPLASTY.

Yasar Mahsut Dincel1, Abdulkadir Sari1, Cagatay Tekin1

  • 1Namık Kemal University, Faculty of Medicine, Department of Orthopedics and Traumatology, Tekirdağ, Turkey.

Acta Ortopedica Brasileira
|November 4, 2020
PubMed
Summary

Total knee arthroplasty (TKA) patients showed a slight, statistically insignificant increase in bone mineral density at the spine and femur one year post-surgery. Bone density largely remained stable after knee replacement surgery.

Keywords:
Bone Density. X-Rays. AbsorptiometryKneeKnee. Osteoporosis. ArthroplastyPhoton. OsteoarthritisReplacement

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Area of Science:

  • Orthopedics
  • Bone Metabolism
  • Radiology

Background:

  • Osteoarthritis significantly impacts knee joint health, often necessitating total knee arthroplasty (TKA).
  • Bone mineral density (BMD) changes after TKA are not fully understood, particularly in the first postoperative year.

Purpose of the Study:

  • To evaluate changes in bone mineral density (BMD) within the first year following total knee arthroplasty (TKA).
  • To assess BMD trends in the spine and proximal femur after TKA for primary knee osteoarthritis.

Main Methods:

  • Dual-energy X-ray absorptiometry (DXA) was used to measure BMD.
  • Preoperative and one-year postoperative DXA scans were analyzed for 76 patients who underwent TKA for knee osteoarthritis.

Main Results:

  • The majority of patients maintained their preoperative BMD status (normal, osteopenia, or osteoporosis).
  • A small number of patients transitioned between BMD categories (e.g., osteopenia to osteoporosis).
  • A statistically insignificant positive trend in T and Z scores was observed at the spine (L1-L4) and proximal femur post-TKA.

Conclusions:

  • Total knee arthroplasty (TKA) resulted in a statistically insignificant bone gain at the spine and proximal femur twelve months post-surgery.
  • Bone mineral density generally remained stable in the first postoperative year for patients undergoing TKA for knee osteoarthritis.