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Rowell Syndrome: A Diagnostic Challenge
Lucia Gallo1,2, Matteo Megna1,2, Bianca Festa1,2
1Drs. Gallo, Megna, Festa, Fabbrocini, and Ferrillo are with the Section of Dermatology in the Department of Clinical Medicine and Surgery at the University of Naples Federico II in Napoli NA, Italy.
Abstract:
BACKGROUND: Rowell syndrome is a rare disease characterized by a combination of lupus erythematosus (LE) and erythema multiforme (EM)-like lesions and a characteristic immunologic pattern, including speckled pattern of antinuclear antibody (ANA), positive anti-Ro/SSA or anti-La/SSB, and positive rheumatoid factor (RF). This disease was first described in 1963, and to date, about 95 cases of EM-like lesions associated with LE have been described in the literature, with the majority of cases being reported in adult female patients. Here, we describe the case of a 17-year-old male patient exhibiting both systemic LE and EM lesions together with ANA and anti-Ro/SSA positivity who was successfully treated with systemic corticosteroids and hydroxychloroquine.
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