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Decreased superoxide dismutase-2 activity in a patient with ring chromosome 6
K Yoshimitsu1, Y Nishi, Y Kobayashi
1Department of Pediatrics, Hiroshima University School of Medicine, Japan.
American Journal of Medical Genetics
|September 1, 1987
Abstract:
Manganese superoxide dismutase (SOD-2) activity was measured in erythrocytes and leukocytes of a patient with ring chromosome 6. Compared to normal control individuals, SOD-2 activity in leukocytes of the patient was lower, whereas cuprozinc SOD (SOD-1) activity was normal. These findings suggest the cause of decreased enzyme activity is the effect of the ring form on production of the enzyme or inherent instability of ring chromosomes.