Diffuse pulmonary micronodules related to prior VZV infection
Kun Yang1,2, Jin Yuan3, Yirong Liu1
1Division of Hospital Medicine, The Miriam Hospital, Providence, RI, 02906, USA.
Respiratory Medicine Case Reports
|November 4, 2020
Summary
Varicella-zoster virus (VZV) infection can lead to calcified pulmonary nodules. A diagnosis of exclusion can identify this rare complication, potentially avoiding invasive procedures.
Area of Science:
- Pulmonology
- Infectious Diseases
- Radiology
Background:
- Chickenpox, caused by Varicella-zoster virus (VZV), is common.
- Pneumonia is a rare complication of VZV infection.
- Calcified pulmonary nodules are an infrequent sequela of healed VZV pneumonia.
Observation:
- A middle-aged female presented with incidental diffuse pulmonary micronodules.
- Further investigation and diagnosis of exclusion linked the nodules to prior VZV infection.
Findings:
- VZV infection can manifest as granulomatous calcified pulmonary nodules.
- Surgical lung biopsy with VZV PCR is the gold standard for diagnosis.
- Diagnosis of exclusion offers a reasonable presumptive diagnosis.
Implications:
- Recognizing VZV-associated pulmonary nodules can prevent unnecessary invasive procedures.
- Familiarity with this rare entity aids in clinical decision-making.
- This finding expands understanding of VZV sequelae.
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