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The effect of neutrophil migration and prolonged neutrophil contact on epithelial permeability
P E Parsons1, K Sugahara, G R Cott
1Department of Medicine, National Immunology and Respiratory Medicine, Denver, CO 80206.
The American Journal of Pathology
|November 1, 1987
Abstract:
The effect of neutrophil migration and prolonged neutrophil contact on epithelial permeability was examined. Although neutrophil migration was not associated with a change in epithelial permeability, prolonged neutrophil-epithelial contact following migration resulted in an increase in epithelial permeability. These results were not altered by catalase, a specific neutrophil elastase inhibitor, methoxysuccinyl-Ala-Ala-Pro-Val-chloromethyl ketone or cyclohexamide. This suggests that neutrophil migration does not occur via an H2O2-induced reversible mechanism of junctional opening, which we describe herein.