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Expression Patterns and Prognostic Values of ORMDL1 in Different Cancers.

Tengjiao Zhu1, Yingtong Chen1, Shuyuan Min1

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|November 4, 2020
PubMed
Summary

The orosomucoid-like 1 (ORMDL1) gene is upregulated in several cancers, including diffuse large B cell lymphoma (DLBCL). ORMDL1 overexpression is linked to poor prognosis and B cell infiltration in DLBCL, suggesting it as a potential therapeutic target.

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Area of Science:

  • Molecular Biology
  • Cancer Research
  • Genetics

Background:

  • The orosomucoid-like gene family (ORMDL) regulates sphingolipid metabolism, impacting cell growth and cancer progression.
  • The specific role of ORMDL1 in various cancers, particularly its expression patterns and prognostic significance, remained largely undefined.

Purpose of the Study:

  • To investigate the expression patterns and prognostic values of ORMDL1 across different tumor types.
  • To specifically analyze ORMDL1 in cholangiocarcinoma (CHOL), diffuse large B cell lymphoma (DLBCL), acute myeloid leukemia (LAML), and thymoma (THYM).

Main Methods:

  • Utilized bioinformatics tools and databases: GEPIA, CCLE, LinkedOmics, cBioPortal, and TIMER.
  • Analyzed gene expression levels, mRNA expression in cell lines, and genetic alterations.
  • Performed Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis.
  • Investigated the correlation between ORMDL1 and tumor-infiltrating immune cells.

Main Results:

  • ORMDL1 was significantly upregulated in tumor tissues of CHOL, DLBCL, LAML, and THYM compared to normal tissues.
  • High ORMDL1 mRNA expression was observed in DLBCL and LAML cell lines.
  • ORMDL1 overexpression correlated with poorer survival in DLBCL patients, with genetic alterations also indicating worse outcomes.
  • ORMDL1 expression positively correlated with infiltrating B cells in DLBCL.

Conclusions:

  • ORMDL1 functions as a tumorigenic factor, particularly in DLBCL.
  • ORMDL1 is a potential prognostic biomarker and therapeutic target for DLBCL.