SARS-CoV-2 in first trimester pregnancy: a cohort study.
N la Cour Freiesleben1,2, P Egerup3, K V R Hviid3
1Department of Obstetrics and Gynaecology, The Fertility Clinic, Copenhagen University Hospital Hvidovre, DK-2650 Hvidovre, Denmark.
Human Reproduction (Oxford, England)
|November 4, 2020
Summary
Maternal infection with severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) in early pregnancy did not impact fetal development, as measured by nuchal translucency thickness. There was no increased risk of pregnancy loss in women infected with SARS-CoV-2 during the first trimester.
Area of Science:
- Obstetrics and Gynecology
- Infectious Diseases
- Fetal Development
Background:
- Pregnant women are more vulnerable to viral infections, with previous coronaviruses linked to adverse outcomes.
- Limited evidence exists on the effects of SARS-CoV-2 in first-trimester pregnancies.
Purpose of the Study:
- To investigate the impact of maternal SARS-CoV-2 infection during the first trimester on fetal development.
- To assess the association between SARS-CoV-2 infection and pregnancy loss in early pregnancy.
Main Methods:
- A cohort study involving 1019 pregnant women undergoing first-trimester screening and 36 with first-trimester pregnancy loss.
- Serum samples were analyzed for SARS-CoV-2 antibodies, correlating results with nuchal translucency thickness and pregnancy loss rates.
Main Results:
- No significant difference in nuchal translucency thickness was observed between pregnant women with and without SARS-CoV-2 antibodies.
- A small number of pregnancy losses occurred in women with SARS-CoV-2 antibodies, but the increased risk was not statistically significant (OR 3.4, P=0.27).
Conclusions:
- Maternal SARS-CoV-2 infection in the first trimester does not appear to affect nuchal translucency thickness or significantly increase pregnancy loss risk in non-hospitalized women.
- Further research is needed to fully understand the risks associated with maternal SARS-CoV-2 infection during pregnancy.
Keywords:
COVID-19SARS-CoV-2coronavirusfirst trimestermaternal infectionnuchal translucencypregnancypregnancy lossMore Related Videos
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