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Bovine kobuvirus-A comprehensive review.

Lili Hao1, Chaoxi Chen1, Keith Bailey2

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|November 4, 2020
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Bovine kobuvirus (BKV), a widespread RNA virus, has been detected globally in cattle. Research suggests BKV may cause neonatal calf diarrhea, necessitating further studies to confirm its pathogenicity.

Keywords:
RT-PCRbovine kobuvirusdetectiongenomic sequencerRT-PCR

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Area of Science:

  • Virology
  • Veterinary Medicine
  • Molecular Biology

Background:

  • Bovine kobuvirus (BKV) is a positive-sense, single-stranded RNA virus belonging to the genus Kobuvirus.
  • First identified in 2003, BKV has since been detected in numerous countries across four continents.
  • Evidence suggests a potential link between BKV and neonatal calf diarrhea.

Purpose of the Study:

  • To review the global detection and genomic characterization of Bovine kobuvirus.
  • To consolidate findings on BKV prevalence and distribution.
  • To assess the potential role of BKV as a causative agent of neonatal calf diarrhea.

Main Methods:

  • Systematic review of published studies on BKV detection.
  • Analysis of genomic characterization data from various BKV isolates.
  • Examination of studies reporting BKV presence in bovine fecal samples.

Main Results:

  • BKV has been detected in bovine fecal samples from 13 countries worldwide.
  • Genomic characterization data from these regions are available.
  • The prevalence of BKV in affected cattle populations is noted.

Conclusions:

  • Bovine kobuvirus is globally distributed in cattle populations.
  • BKV is a potential causative agent of neonatal calf diarrhea.
  • Further research, including animal challenge studies, is required to elucidate BKV pathogenicity.