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Coding and decoding stray magnetic fields for multiplexing kinetic bioassay platform.

Yuan Liu1, Gungun Lin1, Yinghui Chen1

  • 1Institute for Biomedical Materials and Devices, Faculty of Science, The University of Technology Sydney, Ultimo, New South Wales 2007, Australia. gungun.lin@uts.edu.au dayong.jin@uts.edu.au.

Lab on a Chip
|November 4, 2020
PubMed
Summary
This summary is machine-generated.

Stray magnetic fields can now code and decode microscopic beads for multiplexed molecular analysis. This magneto-multiplexing approach offers streamlined assays and potential point-of-care testing solutions.

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Area of Science:

  • Biotechnology
  • Materials Science
  • Nanotechnology

Background:

  • Fluorescently-coded polymer microspheres enable multiplexing but suffer from limitations like quenching, bleaching, spectral cross-talk, and background interference.
  • Current bioassay steps require off-line particle handling, complicating the process.

Purpose of the Study:

  • To develop a novel method for coding and decoding microscopic beads using stray magnetic fields.
  • To overcome the limitations of fluorescent coding for multiplexed molecular analysis.
  • To enable streamlined, on-chip bioassays with integrated particle manipulation.

Main Methods:

  • Hierarchical assembly of mesoscopic superparamagnetic cores into diverse microparticle shapes (spheres, dumbbells, pears, chains, triangles) using microfluidics.
  • Coding of microparticles by creating diverse and non-volatile stray magnetic field responses.
  • Decoding of coded microparticles using a compact giant magnetoresistance (GMR) sensor for parallelized screening.

Main Results:

  • Demonstrated the ability to create unique stray magnetic field fingerprints for different microparticle assemblies.
  • Successfully discerned these magnetic fingerprints using a GMR sensor for parallelized detection.
  • Showcased the potential for magneto-multiplexing in screening multiple pathogenic DNAs.

Conclusions:

  • Stray magnetic field coding offers a robust alternative to fluorescent coding for multiplexed assays.
  • This magneto-multiplexing strategy enables streamlined bioassays, including magneto-mixing, washing, enrichment, and separation.
  • The technology presents a promising solution for point-of-care testing and efficient kinetic assays.