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Association between chronic inflammatory demyelinating polyneuropathy and gastrointestinal malignancies
Adnan Malik1, Rani Berry2, Brian M Fung3
1Division of Hepatology, Loyola University Medical Center, Maywood, IL, USA.
Clinical Journal of Gastroenterology
|November 4, 2020
Summary
Chronic inflammatory demyelinating polyneuropathy (CIDP) is an immune disorder. This review highlights the rare but important link between CIDP and gastrointestinal cancers, emphasizing timely diagnosis and treatment.
Area of Science:
- Neurology
- Immunology
- Gastroenterology
Background:
- Chronic inflammatory demyelinating polyneuropathy (CIDP) is an uncommon immune-mediated peripheral nervous system disorder.
- CIDP has diverse causes, including infections and non-infectious triggers, with various presentations.
- A rare association exists between CIDP and gastrointestinal malignancies.
Purpose of the Study:
- To provide a practical overview of CIDP.
- To emphasize the clinical association between CIDP and gastrointestinal malignancies.
- To aid in recognizing this specific CIDP etiology.
Main Methods:
- Literature review focusing on CIDP and gastrointestinal malignancies.
- Analysis of diagnostic timing and treatment responses.
- Synthesis of clinical information for practical guidance.
Main Results:
- CIDP diagnosis often precedes gastrointestinal malignancy by weeks to months, but the reverse can occur.
- Treatment with corticosteroids, IVIg, or plasma exchange is common for CIDP associated with GI cancers.
- Neurological symptom improvement or resolution is observed in most cases.
Conclusions:
- Recognizing the link between CIDP and gastrointestinal cancers is crucial for early diagnosis.
- Prompt treatment of CIDP in this context can lead to favorable neurological outcomes.
- This association warrants consideration in the differential diagnosis of CIDP.
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