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Related Experiment Video

Updated: Dec 2, 2025

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein
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Plasma tau predicts cerebral vulnerability in aging.

Jose L Cantero1,2, Mercedes Atienza1,2, Jaime Ramos-Cejudo3

  • 1Laboratory of Functional Neuroscience, Pablo de Olavide University, Seville, Spain.

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Plasma total tau (t-tau) can identify early brain changes and memory loss in older adults. This blood biomarker may help detect individuals at risk for neurodegenerative diseases.

Keywords:
FDG-PETagingcerebral vulnerabilitycortical thicknessplasma tau

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Area of Science:

  • Neuroscience
  • Gerontology
  • Biomarker Discovery

Background:

  • Aging-related chronic diseases are a growing concern.
  • Early detection of cerebral vulnerability in the elderly is crucial for prevention.
  • Non-invasive biomarkers for subclinical brain changes in older adults are needed.

Purpose of the Study:

  • To investigate plasma total tau (t-tau) as a biomarker for cerebral and cognitive deficits in normal aging.
  • To assess the association between plasma t-tau and measures of brain health and memory.

Main Methods:

  • Measured plasma total tau (t-tau) levels in elderly subjects.
  • Assessed cortical thickness and cortical glucose metabolism as indicators of cerebral vulnerability.
  • Evaluated memory function.

Main Results:

  • Elevated plasma t-tau levels correlated with reduced cortical glucose uptake.
  • Increased plasma t-tau was linked to temporal lobe thinning and memory deficits.
  • Orbitofrontal cortex glucose metabolism mediated the link between cortical thinning and memory loss.

Conclusions:

  • Plasma t-tau shows potential as a non-invasive biomarker for identifying subclinical brain and cognitive deficits in normal aging.
  • This biomarker may aid in detecting individuals at risk for age-related neurodegenerative conditions.