Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

1.4K
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
1.4K
Neuroplasticity01:01

Neuroplasticity

1.2K
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
1.2K
Neuron Structure01:31

Neuron Structure

229.1K
Overview
229.1K
Neuron Structure01:30

Neuron Structure

16.7K
Neurons are the main type of cell in the nervous system that generate and transmit electrochemical signals. They primarily communicate with each other using neurotransmitters at specific junctions called synapses. Neurons come in many shapes that often relate to their function, but most share three main structures: an axon and dendrites that extend out from a cell body.
Structure and Function of Neurons
The neuronal cell body—the soma— houses the nucleus and organelles vital to...
16.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Snooping helices: The elastic path finding algorithm of growing hyphae.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Deformation under flow and morphological recovery of cancer cells.

Lab on a chip·2024
Same author

Synapses do not facilitate prion-like transfer of alpha-synuclein: a quantitative study in reconstructed unidirectional neural networks.

Cellular and molecular life sciences : CMLS·2023
Same author

Bending stiffness of <i>Candida albicans</i> hyphae as a proxy of cell wall properties.

Lab on a chip·2022
Same author

Parallelized Manipulation of Adherent Living Cells by Magnetic Nanoparticles-Mediated Forces.

International journal of molecular sciences·2020
Same author

High-resolution Volume Imaging of Neurons by the Use of Fluorescence eXclusion Method and Dedicated Microfluidic Devices.

Journal of visualized experiments : JoVE·2018

Related Experiment Video

Updated: Dec 2, 2025

High-resolution Volume Imaging of Neurons by the Use of Fluorescence eXclusion Method and Dedicated Microfluidic Devices
09:11

High-resolution Volume Imaging of Neurons by the Use of Fluorescence eXclusion Method and Dedicated Microfluidic Devices

Published on: March 26, 2018

7.3K

Neuronal growth from a volume perspective.

Céline Braïni1, Ghislain Bugnicourt2, Catherine Villard1

  • 1Physico-Chimie Curie, CNRS UMR 168, Université PSL, Sorbonne Université, Paris, France.

Physical Biology
|November 4, 2020
PubMed
Summary
This summary is machine-generated.

Actin waves supply volume to developing neuronal growth cones. This study used microfluidics to show actin waves and growth cones lose volume, with waves transferring material to cones, suggesting membrane recycling.

More Related Videos

Intraventricular Transplantation of Engineered Neuronal Precursors for In Vivo Neuroarchitecture Studies
15:00

Intraventricular Transplantation of Engineered Neuronal Precursors for In Vivo Neuroarchitecture Studies

Published on: May 11, 2019

5.9K
Rewiring Neuronal Circuits: A New Method for Fast Neurite Extension and Functional Neuronal Connection
10:26

Rewiring Neuronal Circuits: A New Method for Fast Neurite Extension and Functional Neuronal Connection

Published on: June 13, 2017

9.1K

Related Experiment Videos

Last Updated: Dec 2, 2025

High-resolution Volume Imaging of Neurons by the Use of Fluorescence eXclusion Method and Dedicated Microfluidic Devices
09:11

High-resolution Volume Imaging of Neurons by the Use of Fluorescence eXclusion Method and Dedicated Microfluidic Devices

Published on: March 26, 2018

7.3K
Intraventricular Transplantation of Engineered Neuronal Precursors for In Vivo Neuroarchitecture Studies
15:00

Intraventricular Transplantation of Engineered Neuronal Precursors for In Vivo Neuroarchitecture Studies

Published on: May 11, 2019

5.9K
Rewiring Neuronal Circuits: A New Method for Fast Neurite Extension and Functional Neuronal Connection
10:26

Rewiring Neuronal Circuits: A New Method for Fast Neurite Extension and Functional Neuronal Connection

Published on: June 13, 2017

9.1K

Area of Science:

  • Cell Biology
  • Neuroscience
  • Biophysics

Background:

  • Neuronal development involves complex actin dynamics.
  • Growth cones and actin waves are key actin-rich structures in early neuronal growth.
  • Understanding material transport during neuronal development is crucial.

Purpose of the Study:

  • To investigate the volume dynamics of growth cones and actin waves during neuronal development.
  • To elucidate the relationship between actin waves and growth cone material supply.
  • To explore potential membrane recycling mechanisms associated with actin waves.

Main Methods:

  • Utilized a microfluidic-based fluorescent exclusion method.
  • Studied volume changes in growth cones and actin waves in developing neurons.

Main Results:

  • Both growth cones and actin waves exhibit volume loss during their progression.
  • Actin waves transfer their remaining volume to growth cones.
  • Evidence suggests actin waves act as a pulsatile anterograde source of material.

Conclusions:

  • Actin waves appear to supply material to increasingly distant growth cones.
  • A potential membrane recycling phenomenon associated with actin waves is suggested.
  • Actin waves may facilitate both pulsatile anterograde and continuous retrograde transport.