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Manifestations of sepsis
R L Harris1, D M Musher, K Bloom
1Department of Medicine, Baylor College of Medicine, Houston, TX.
Archives of Internal Medicine
|November 1, 1987
Summary
Early recognition of sepsis signs and symptoms is crucial for prompt management. This review details sepsis manifestations, focusing on cardiopulmonary changes across shock states and guiding therapy.
Area of Science:
- Medical Science
- Clinical Medicine
- Pathophysiology
Background:
- Sepsis presents with varied clinical signs, ranging from obvious to subtle.
- Early identification of sepsis is critical for effective treatment.
- Understanding sepsis pathophysiology aids in managing its diverse manifestations.
Purpose of the Study:
- To review the clinical presentation and pathophysiology of sepsis.
- To emphasize cardiopulmonary manifestations of sepsis.
- To provide therapeutic guidelines for sepsis management.
Main Methods:
- Literature review of sepsis clinical manifestations.
- Analysis of pathophysiologic understanding.
- Examination of cardiopulmonary changes in preshock, early shock, and late shock.
Main Results:
- Sepsis clinical signs can be overt or insidious.
- Cardiopulmonary manifestations evolve through distinct shock phases.
- Treatment may require addressing both the infection and its specific symptoms.
Conclusions:
- Awareness of sepsis signs facilitates early intervention.
- Understanding temporal cardiopulmonary changes informs treatment strategies.
- Targeted therapy for sepsis manifestations is essential alongside infection control.