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Aortic Prosthesis-Associated MDR Pseudomonas Infections as a Diagnostic and Therapeutic Challenge
Rita Filipe1,2, Filipa Ceia1,2, Ana Cláudia Carvalho1
1Infectious Diseases Department, São João University Hospital Center, 4000-319 Porto, Portugal.
Abstract:
Endovascular prostheses are used to treat life-threatening conditions such as ruptured aortic aneurysms. Prosthetic infection cause significant morbidity and mortality, posing important diagnostic and therapeutic challenges. It is particularly difficult to diagnose and, in the era of multidrug resistance (MDR), these type of infections may become even more difficult to treat. Herein, we reported a case of a secondary prosthetic endovascular infection following repeated bacteremia episodes from a urinary source. This case illustrates an MDR Pseudomonas aeruginosa aortic infection that was difficult to diagnose with no oral antibiotic treatment options.
Insights
Prosthetic endovascular infections, especially those caused by multidrug-resistant bacteria like Pseudomonas aeruginosa, present significant diagnostic and treatment challenges. This case highlights a difficult-to-diagnose aortic infection with limited oral antibiotic options.
Area of Science:
- Vascular Surgery
- Infectious Diseases
- Medical Microbiology
Background:
- Endovascular prostheses are critical for treating conditions like ruptured aortic aneurysms.
- Infections of these prostheses lead to severe complications, including high morbidity and mortality.
- Diagnosing and treating prosthetic infections is challenging, particularly with rising antimicrobial resistance.
Observation:
- A case of secondary endovascular prosthetic infection is presented.
- The infection followed recurrent bacteremia originating from a urinary source.
- The causative agent was identified as multidrug-resistant Pseudomonas aeruginosa.
Findings:
- The aortic infection was difficult to diagnose.
- Multidrug-resistant Pseudomonas aeruginosa was identified as the pathogen.
- There were no suitable oral antibiotic treatment options available.
Implications:
- This case underscores the diagnostic difficulties associated with prosthetic endovascular infections.
- It highlights the challenges in treating infections caused by multidrug-resistant organisms.
- The lack of oral treatment options for such infections necessitates careful management and potentially novel therapeutic strategies.
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