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Does colchicine work? The results of the first controlled study in acute gout
M J Ahern1, C Reid, T P Gordon
1Department of Medicine, Flinders University of South Australia.
Australian and New Zealand Journal of Medicine
|June 1, 1987
Abstract:
We have performed the first controlled study of colchicine in acute gout, to determine its efficacy and toxicity, and to define the natural history of acute gout. Two-thirds of colchicine-treated patients improved after 48 hours, but only one-third of the patients receiving placebo demonstrated similar improvement. The colchicine-treated patients responded earlier; significant differences from placebo were shown after 18-30 hours. All patients given colchicine developed diarrhea after a median time of 24 hours (mean dose of colchicine 6.7 mg). This side effect occurred before relief of pain in most patients.