Related Experiment Video
Updated: Dec 2, 2025

Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections
Published on: February 2, 2024
Staphylococcus schleiferi diabetic foot osteomyelitis and bacteraemia in an immunocompromised host
Minh Thu Thi Nguyen1, Nicholas R Ahern2, Meghan K Train2
1Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA MinhThu_Nguyen@URMC.Rochester.edu.
Abstract:
Staphylococcus schleiferi is a Gram-positive coccus bacterium first discovered in 1988 that is typically associated with skin and ear infections in dogs, cats and birds. It is infrequently described as a human pathogen. There are, however, emerging reports of S. schleiferi infections in diverse clinical scenarios in humans, particularly in patients with weakened immune systems. S. schleiferi may be underrecognised due to limitations in routine microbiology diagnostic protocols and mislabelling as other Staphylococcus sp. We present a rare case of S. schleiferi diabetic foot osteomyelitis with subsequent bacteraemia in an immunocompromised host.
Insights
Staphylococcus schleiferi, a bacterium rarely causing human infections, can lead to severe conditions like diabetic foot osteomyelitis and bloodstream infections in immunocompromised individuals. This case highlights the need for better diagnostic recognition of this emerging pathogen.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Clinical Bacteriology
Background:
- Staphylococcus schleiferi is a Gram-positive coccus primarily known for causing infections in animals.
- Its role as a human pathogen is increasingly recognized, particularly in vulnerable populations.
- Underdiagnosis may occur due to limitations in standard microbiological identification methods.
Observation:
- A rare case of Staphylococcus schleiferi infection is presented.
- The infection manifested as diabetic foot osteomyelitis.
- The patient experienced subsequent bacteraemia (bloodstream infection).
Findings:
- The study details a specific instance of S. schleiferi causing severe invasive disease.
- The patient was immunocompromised, a key risk factor for opportunistic infections.
- This case underscores the potential for S. schleiferi to cause serious human infections.
Implications:
- Highlights the importance of considering S. schleiferi in human infections, especially in immunocompromised hosts.
- Suggests a need for improved diagnostic strategies to accurately identify S. schleiferi.
- Contributes to understanding the evolving spectrum of Staphylococcus-related human diseases.
Related Concept Videos
Skin Diseases and Disorders
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
Pulmonary Tuberculosis I
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Defense Against Bacterial Pathogens
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Fungal Phylum Microsporidia
Immunodeficiency Diseases
There are three main causes of immunodeficiency...

