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Primary pulmonary Ewing sarcoma/peripheral primitive neuroectodermal tumor.
Aaron J Sohn1, Benjamin Lang1, Michael McCarroll2
1Department of Pathology, Baylor University Medical Center, Dallas, Texas.
This report details a rare case of Ewing sarcoma/primitive neuroectodermal tumor (ES/pPNET) found in the lung of a 49-year-old woman. This finding highlights the uncommon occurrence of primary pulmonary ES/pPNET.
Area of Science:
- Oncology
- Pathology
- Genetics
Background:
- Ewing sarcoma/primitive neuroectodermal tumor (ES/pPNET) is a rare malignant small round cell sarcoma.
- It typically affects children, adolescents, and adults, with primary lung involvement being exceptionally uncommon.
Observation:
- A 49-year-old woman with a BRCA2 mutation underwent screening imaging.
- A mass was detected in her right lung during this screening.
Findings:
- Histological, immunohistochemical, and molecular analyses confirmed the lung mass as ES/pPNET.
- This represents a rare instance of primary pulmonary Ewing sarcoma.
Implications:
- This case contributes to the limited understanding of primary pulmonary ES/pPNET.
- It underscores the importance of considering rare diagnoses in lung masses, even in the context of genetic predispositions like BRCA2 mutations.
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