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In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis

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Published on: December 9, 2016

Primary pulmonary Ewing sarcoma/peripheral primitive neuroectodermal tumor.

Aaron J Sohn¹, Benjamin Lang¹, Michael McCarroll²

¹Department of Pathology, Baylor University Medical Center, Dallas, Texas.

Proceedings (Baylor University. Medical Center)

|November 5, 2020

Summary

This summary is machine-generated.

This report details a rare case of Ewing sarcoma/primitive neuroectodermal tumor (ES/pPNET) found in the lung of a 49-year-old woman. This finding highlights the uncommon occurrence of primary pulmonary ES/pPNET.

Keywords:

Ewing sarcoma peripheral primitive neuroectodermal tumor primary lung tumor

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Area of Science:

Oncology
Pathology
Genetics

Background:

Ewing sarcoma/primitive neuroectodermal tumor (ES/pPNET) is a rare malignant small round cell sarcoma.
It typically affects children, adolescents, and adults, with primary lung involvement being exceptionally uncommon.

Observation:

A 49-year-old woman with a BRCA2 mutation underwent screening imaging.
A mass was detected in her right lung during this screening.

Findings:

Histological, immunohistochemical, and molecular analyses confirmed the lung mass as ES/pPNET.
This represents a rare instance of primary pulmonary Ewing sarcoma.

Implications:

This case contributes to the limited understanding of primary pulmonary ES/pPNET.
It underscores the importance of considering rare diagnoses in lung masses, even in the context of genetic predispositions like BRCA2 mutations.