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Related Experiment Video

Updated: Dec 2, 2025

Identification of Circular RNAs using RNA Sequencing
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Identification of Circular RNAs using RNA Sequencing

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Microarray Expression Profiles and Bioinformatics Analyses Reveal Aberrant Circular RNAs Expression in Bladder

Jun Yang1, Junwen Chen2, Si Wu3

  • 1Department of Gastroenterology, Shengjing Hospital of China Medical University, Shenyang 110004, People's Republic of China.

Oncotargets and Therapy
|November 5, 2020
PubMed
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This study identified differentially expressed circular RNAs (circRNAs) in bladder cancer (BCa), revealing their potential roles in the disease's molecular development. These findings highlight circRNAs as key players in BCa pathogenesis.

Area of Science:

  • Molecular Biology
  • Genomics
  • Cancer Research

Background:

  • Circular RNAs (circRNAs) are increasingly recognized for their roles in biological processes.
  • circRNAs function as microRNA (miRNA) sponges, regulating gene expression.
  • Understanding circRNA expression is crucial for elucidating disease mechanisms.

Purpose of the Study:

  • To identify differentially expressed circRNAs in bladder cancer (BCa).
  • To investigate the potential molecular mechanisms involving these circRNAs in BCa.

Main Methods:

  • circRNA transcriptome profiling in BCa using microarray analysis.
  • Validation of differentially expressed circRNAs via quantitative real-time PCR.
  • Prediction of miRNA response elements (MREs) and pathway/ontology enrichment analysis.
Keywords:
bioinformatics analysisbladder cancercircular RNAsmicroarraynoncoding RNAs

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Related Experiment Videos

Last Updated: Dec 2, 2025

Identification of Circular RNAs using RNA Sequencing
08:25

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

12.6K
Cell-Free DNA Integrity Analysis in Urine Samples
07:58

Cell-Free DNA Integrity Analysis in Urine Samples

Published on: January 5, 2017

14.1K
miRNA Expression Analyses in Prostate Cancer Clinical Tissues
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miRNA Expression Analyses in Prostate Cancer Clinical Tissues

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Main Results:

  • Identification of 386 up-regulated and 394 down-regulated circRNAs in BCa.
  • Prediction of potential MREs for the identified circRNAs.
  • Elucidation of potential regulatory mechanisms associated with differentially expressed circRNAs.

Conclusions:

  • Differentially expressed circRNAs are significantly altered in bladder cancer.
  • circRNAs likely play crucial roles in the molecular pathogenesis of BCa.
  • These findings provide a foundation for further research into circRNA-based diagnostics and therapeutics for BCa.