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Related Experiment Videos

Involucrin expression in skin appendage tumours.

T Hashimoto1, N Inamoto, K Nakamura

  • 1Section of Dermatology, Kitasato Institute Hospital, Tokyo, Japan.

The British Journal of Dermatology
|September 1, 1987
PubMed
Summary

Involucrin expression aids in distinguishing skin tumors. Hair follicle tumors strongly express involucrin, while most sweat gland tumors do not, aiding in origin determination.

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Area of Science:

  • Dermatopathology
  • Oncology
  • Immunohistochemistry

Background:

  • Involucrin is a key protein in epidermal differentiation.
  • Accurate classification of skin appendage tumors is crucial for diagnosis and treatment.
  • The origin of some skin tumors remains controversial.

Purpose of the Study:

  • To investigate the expression patterns of involucrin in various skin appendage tumors.
  • To assess the utility of involucrin as a marker for tumor origin and differentiation.
  • To differentiate between tumors of hair follicle and sweat gland origin.

Main Methods:

  • Immunoperoxidase technique used to detect involucrin expression.
  • Analysis of 23 hair follicle, 17 sweat gland, and 3 unknown origin skin tumors.

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  • Comparison of involucrin staining patterns with known histological features.

    • Main Results:

    • All hair follicle origin tumors showed positive involucrin staining, especially keratoacanthoma and squamous eddies.
    • Trichofolliculoma, trichilemmoma, and pilomatrixoma displayed characteristic patterns similar to normal hair follicles.
    • Most sweat gland tumors showed no staining, except for areas of lumen formation or squamous metaplasia.
    • Desmoplastic trichoepithelioma stained positively, unlike syringoma.
    • Clear cell acanthoma showed a pattern suggesting a non-sweat gland origin.

    Conclusions:

    • Involucrin expression is a valuable marker for differentiating skin appendage tumors.
    • The study supports the use of involucrin to understand tumor maturation kinetics.
    • Involucrin staining can aid in determining the precise origin of controversial skin tumors.