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Published on: January 12, 2020
Trichloroethylene increases pulmonary endothelial permeability: implication for pulmonary veno-occlusive disease
Julien Caliez1,2,3, Marianne Riou1,2,3,4, Grégoire Manaud1,2
1School of Medicine, Université Paris-Saclay, Le Kremlin-Bicêtre, France.
Abstract:
Trichloroethylene exposure is a major risk factor for pulmonary veno-occlusive disease. We demonstrated that trichloroethylene alters the endothelial barrier integrity, at least in part, through vascular endothelial (VE)-Cadherin internalisation, and suggested that this mechanism may play a role in the development of pulmonary veno-occlusive disease.
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