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Bulk-phase-error correction for phase-sensitive signal processing of optical coherence tomography.

Kensuke Oikawa1, Daisuke Oida1, Shuichi Makita1

  • 1Computational Optics Group, University of Tsukuba, Tsukuba, Ibaraki, 305-8573, Japan.

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|November 5, 2020
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Summary

This study introduces a new numerical method to stabilize phase in optical coherence tomography (OCT) imaging. The technique corrects phase errors from sample motion and environmental changes, significantly improving image quality.

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Area of Science:

  • Biomedical Optics
  • Medical Imaging
  • Signal Processing

Background:

  • Phase-sensitive signal processing in Optical Coherence Tomography (OCT) is crucial for detailed analysis.
  • Axial bulk motion and environmental perturbations introduce phase errors, degrading image quality during volumetric OCT acquisition.

Purpose of the Study:

  • To develop and validate a numerical phase stabilization method for phase-sensitive OCT signal processing.
  • To address and correct bulk phase errors caused by sample motion and environmental factors.

Main Methods:

  • A novel numerical method computes partial derivatives of phase error along scanning directions to create a vectorial gradient field.
  • A smart integration path method is employed to estimate phase error from the vectorial gradient field.

Main Results:

  • Analysis of spatial frequency spectra of en face OCT images demonstrated significant phase error correction.
  • Computationally refocused en face images of ex vivo tissue samples showed marked improvement in image quality post-correction.

Conclusions:

  • The presented numerical phase stabilization method effectively removes bulk phase errors in OCT.
  • This technique enhances image quality in phase-sensitive OCT, enabling more accurate analysis of biological tissues.