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Secretory processes in lymphocyte function.

P Henkart1, M Henkart, R Hodes

  • 1Immunology Branch, NCI, Bethesda, MD 20892.

Bioscience Reports
|April 1, 1987
PubMed
Summary
This summary is machine-generated.

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T lymphocytes utilize a regulated protein secretion pathway, storing proteins in granules. This pathway is activated by T cell receptor complex signaling, similar to cytotoxic lymphocytes and other specialized cells.

Area of Science:

  • Immunology
  • Cell Biology
  • Protein Secretion

Background:

  • Immunoglobulin secretion by plasma cells follows a non-regulated pathway.
  • The secretion pathway for lymphokines by T lymphocytes remains unclear, with possibilities including non-regulated or regulated pathways.

Purpose of the Study:

  • To investigate whether T lymphocytes utilize a regulated pathway for lymphokine secretion.
  • To compare the secretion mechanisms in helper T cells and cytotoxic T lymphocytes.

Main Methods:

  • Measuring the release of granule serine protease in cytotoxic T lymphocytes.
  • Analyzing the response of cloned T helper cells to various stimuli, including antigen, antibodies, and chemical activators.

Main Results:

Related Experiment Videos

  • Cytotoxic T lymphocytes secrete granule serine protease upon triggering by target cells or antibodies binding the T cell receptor.
  • Helper T lymphocytes also store serine protease in acidic cytoplasmic granules and secrete it in response to processed antigen, anti-T cell receptor antibodies, or phorbol ester/calcium ionophore combinations.
  • The regulated secretion pathway is demonstrably active in both helper and cytotoxic T lymphocytes following T cell antigen receptor activation.

Conclusions:

  • Both helper and cytotoxic T lymphocytes employ a regulated protein secretion pathway.
  • This regulated pathway is activated via the T cell antigen receptor complex, involving intracellular storage and triggered release.