Related Experiment Video

Updated: Dec 2, 2025

Using Extraordinary Optical Transmission to Quantify Cardiac Biomarkers in Human Serum
09:23

Using Extraordinary Optical Transmission to Quantify Cardiac Biomarkers in Human Serum

Published on: December 13, 2017

6.6K

High-Sensitivity Cardiac Troponin I for Risk Stratification in Older Adults

Olive Tang1, Kunihiro Matsushita1, Josef Coresh1

  • 1Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

Journal of the American Geriatrics Society
|November 5, 2020
PubMed

Insights

High-sensitivity cardiac troponin I (hs-cTnI) improves cardiovascular risk prediction in older adults. Elevated hs-cTnI identifies high-risk individuals, even without prior cardiovascular disease (CVD), offering better discrimination than hs-troponin T (hs-cTnT).

Area of Science:

  • Cardiology
  • Biomarkers
  • Geriatric Medicine

Background:

  • Traditional cardiovascular risk factors are less predictive in older adults.
  • High-sensitivity cardiac troponin I (hs-cTnI) indicates subclinical cardiomyocyte damage and is linked to cardiovascular risk in middle-aged populations.
  • The predictive value of hs-cTnI in older adults requires further investigation, particularly in comparison to hs-troponin T (hs-cTnT).

Purpose of the Study:

  • To evaluate if hs-cTnI predicts mortality and cardiovascular risk in older adults beyond traditional factors.
  • To compare the discriminatory power of hs-cTnI versus hs-cTnT in this population.
  • To identify high-risk individuals using hs-cTnI levels, irrespective of existing cardiovascular disease (CVD).

Main Methods:

  • Prospective cohort study of 5,876 participants (ages 66-90) from the Atherosclerosis Risk in Communities (ARIC) Study.
  • Cox regression analysis assessed the association of hs-cTnI categories with mortality and incident CVD (atherosclerotic CVD, heart failure).
  • Analyses were adjusted for traditional cardiovascular risk factors and compared hs-cTnI's performance against hs-cTnT.

Main Results:

  • Elevated hs-cTnI was independently associated with increased mortality (HR=2.38) and incident CVD (HR=3.41), ASCVD (HR=2.02), and heart failure (HR=6.16).
  • Participants with elevated hs-cTnI but no prior CVD had mortality risks comparable to those with established CVD.
  • hs-cTnI significantly improved risk prediction models and demonstrated greater discrimination than hs-cTnT for cardiovascular mortality and heart failure.

Conclusions:

  • hs-cTnI enhances mortality and CVD risk stratification in older adults, surpassing traditional risk factors.
  • Elevated hs-cTnI identifies a high-risk group, even in the absence of diagnosed CVD.
  • hs-cTnI offers superior risk discrimination for specific cardiovascular outcomes compared to hs-cTnT in older populations.
Abstract

Keywords:
cardiovascular risk stratificationepidemiologyheart failurehigh-sensitivity troponin

More Related Videos

Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training07:40

Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training

Published on: October 10, 2019

7.6K
A Sensitive and Specific Quantitation Method for Determination of Serum Cardiac Myosin Binding Protein-C by Electrochemiluminescence Immunoassay10:12

A Sensitive and Specific Quantitation Method for Determination of Serum Cardiac Myosin Binding Protein-C by Electrochemiluminescence Immunoassay

Published on: August 8, 2013

17.0K

Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
622
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
114
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
245
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
432
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
386
Imaging Studies for Cardiovascular System V: CT01:28

Imaging Studies for Cardiovascular System V: CT

Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
161