Suppression of Insulin Secretion in the Treatment of Obesity: A Systematic Review and Meta-Analysis

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Zhengxiang Huang1, Weihao Wang1,2,3, Lili Huang1

  • 1School of Biomedical Sciences, University of Queensland, St Lucia, Brisbane, Queensland, Australia.

Obesity (Silver Spring, Md.)
|November 5, 2020
PubMed
Abstract

Insights

Suppressing insulin secretion may help reduce body weight and fat mass in obese individuals. This approach led to significant weight loss but a slight increase in blood glucose levels.

Area of Science:

  • Endocrinology and Metabolism
  • Pharmacology
  • Obesity Research

Background:

  • Obesity is a complex metabolic disorder with significant health implications.
  • Current obesity treatments have varying efficacy and safety profiles.
  • Targeting insulin secretion presents a potential therapeutic avenue for weight management.

Purpose of the Study:

  • To evaluate the efficacy and safety of suppressing insulin secretion for obesity treatment.
  • To synthesize evidence from randomized controlled trials on drugs that directly suppress insulin secretion.

Main Methods:

  • Systematic literature search of PubMed, Embase, and Cochrane databases up to January 1, 2020.
  • Inclusion of randomized controlled trials using diazoxide or octreotide to suppress insulin secretion.
  • Meta-analysis of extracted data using random-effects models.

Main Results:

  • Seven trials were included (4 diazoxide, 3 octreotide).
  • Insulin suppression significantly reduced fasting insulin but slightly increased fasting blood glucose.
  • Significant reductions in body weight, BMI, and fat mass were observed compared to placebo.

Conclusions:

  • Suppression of insulin secretion shows potential for reducing body weight and fat mass in obesity.
  • This intervention may lead to a slight increase in blood glucose levels.
  • Further research is warranted to confirm safety and long-term efficacy.

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