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Ultrathin Porated Elastic Hydrogels As a Biomimetic Basement Membrane for Dual Cell Culture
Published on: December 26, 2017
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A minimalistic catalytically-active cell mimetic made of a supra-molecular hydrogel encapsulated into a polymersome
Rosa Martí-Centelles1, Jenifer Rubio-Magnieto, Beatriu Escuder
1Departament de Química Inorgànica i Orgànica, Universitat Jaume I, Castelló 12071, Spain. escuder@uji.es.
Abstract:
A minimalistic multicomponent cell mimetic is described consisting of a fibrillar network formed by the self-assembly of a low molecular weight compound (cytoskeleton-like) that is entrapped into a polymersome (membrane-like), namely a jelly-polymersome. A simple imidazole-appended hydrogelator is used in order to obtain a catalytic nanoreactor able to hydrolyze an ester within the compartment in its self-assembled state.

