Related Experiment Videos
Corticotropin-releasing factor (CRF) produces analgesia in humans and rats
K M Hargreaves1, G P Mueller, R Dubner
1Clinical Pain Section, National Institute of Dental Research, Bethesda, MD 20892.
Brain Research
|September 29, 1987
Abstract:
The analgesic activity of corticotropin releasing factor (CRF) was determined in a clinical model and in the rat hot plate test. Patients administered CRF reported significantly less postoperative pain than patients pretreated with placebo. In rats, injection of CRF resulted in a significant analgesia which was comparable in both intensity and duration to a 300 times greater molar dose of morphine. These findings suggest that endogenous CRF may play a physiologic role in modulating pain when released under conditions of stress.