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The Association Between Ocular Rigidity and Neuroretinal Damage in Glaucoma
Diane N Sayah1,2, Javier Mazzaferri1, Denise Descovich1
1Maisonneuve-Rosemont Hospital Research Center, Montreal, Quebec, Canada.
Investigative Ophthalmology & Visual Science
|November 5, 2020
Summary
Lower ocular rigidity is linked to increased neuroretinal damage in open-angle glaucoma patients. This study highlights ocular rigidity
Area of Science:
- Ophthalmology
- Biomechanical Engineering
- Glaucoma Research
Background:
- Ocular rigidity (OR) is a key biomechanical property implicated in the pathophysiology of open-angle glaucoma (OAG).
- Understanding the relationship between ocular biomechanics and glaucoma-related neuroretinal damage is crucial for disease management.
Purpose of the Study:
- To investigate the correlation between ocular rigidity (OR) and the extent of neuroretinal damage in patients with open-angle glaucoma (OAG).
- To compare the association of OR with glaucomatous damage against other corneal biomechanical parameters.
Main Methods:
- Employed a noninvasive optical coherence tomography (OCT)-based method to measure ocular rigidity (OR) in 108 subjects.
- Assessed glaucomatous damage using ganglion cell complex (GCC) thickness, retinal nerve fiber layer (RNFL) thickness, and neuroretinal rim area.
- Utilized Pearson and partial correlations, adjusting for age, sex, and ethnicity.
Main Results:
- Found significant positive correlations between ocular rigidity and GCC thickness, rim area, and RNFL thickness in superior and inferior quadrants.
- These correlations with ocular rigidity were generally stronger than those observed for central corneal thickness (CCT), corneal hysteresis (CH), and corneal resistance factor (CRF).
- No significant correlation was identified between ocular rigidity and other corneal biomechanical parameters.
Conclusions:
- A positive correlation exists between ocular rigidity and structural OCT-based parameters, suggesting that lower ocular rigidity is associated with greater neuroretinal damage in OAG.
- These findings offer valuable insights into the biomechanical factors contributing to the pathophysiology of open-angle glaucoma.
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