Pathomechanisms and Predisposing Factors for Degenerative Lumbar Spondylolisthesis: A Narrative Review

The pathomechanism of degenerative lumbar spondylolisthesis (DLS) is not fully understood and is likely to be multifactorial. The primary cause of DLS likely is age-related degeneration of all of the components of the segments and their surroundings. Subsequently, additional factors, such as anatomical, hormonal, and mechanical stress factors, may drive the spinal segments to DLS. Reported predisposing factors that have shown a consistent association with DLS include older age, female sex, sagittal facet joint orientation, and high pelvic incidence. Future prospective epidemiological studies that include large groups of subjects and use multivariate analyses of the possible predisposing factors are needed.