Adapting pharmacological dose-finding designs for early phase behavioral intervention development research
Elizabeth Kuhl Towner1, April Idalski Carcone1, Samiran Ghosh1
1Department of Family Medicine and Public Health Sciences.
Summary
Systematic dose-finding methods are crucial for behavioral health interventions. Adapting drug development
Area of Science:
- Behavioral health intervention development
- Clinical trial design
- Health services research
Background:
- Behavioral intervention development lacks systematic dose-finding designs.
- Drug development utilizes established, iterative dose-finding pathways.
- Behavioral interventions can benefit from rigorous dose optimization.
Purpose of the Study:
- To discuss the current state of dose-finding in behavioral intervention development.
- To present an adaptable dose-finding methodology from drug development.
- To illustrate the application of dose-finding for behavioral interventions.
Main Methods:
- Review of dose-finding methodologies in behavioral intervention literature.
- Detailed overview of the Accelerated Biased Coin Up-and-Down design.
- Application of the design to adapt the Prevention Plus Intervention for pediatric obesity via mHealth.
Main Results:
- The Accelerated Biased Coin Up-and-Down design offers a feasible and rigorous approach.
- Empirically deriving behavioral intervention dose is achievable.
- The adapted Prevention Plus Intervention serves as a case study for dose optimization.
Conclusions:
- Adapting drug development dose-finding enhances behavioral intervention development.
- Systematic dose determination improves intervention feasibility and efficiency.
- This approach strengthens the scientific rigor of behavioral interventions.
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