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Modified poly(3-hydroxybutyrate)-based scaffolds in tissue engineering applications: A review
Sanaz Soleymani Eil Bakhtiari1, Saeed Karbasi2, Elahe Bahremandi Toloue2
1Advanced Materials Research Center, Department of Materials Engineering, Najafabad Branch, Islamic Azad University, Najafabad, Iran.
International Journal of Biological Macromolecules
|November 5, 2020
Summary
Poly(3-hydroxybutyrate) (PHB), a biocompatible polymer, shows promise in tissue engineering. This review explores PHB alloys and composites fabricated using methods like electrospinning for enhanced scaffold properties.
Area of Science:
- Biomaterials Science
- Polymer Science
- Tissue Engineering
Background:
- Poly(3-hydroxybutyrate) (PHB) is a notable member of the polyhydroxyalkanoate (PHA) family.
- PHB offers excellent biocompatibility, non-toxic degradation products, and high mechanical strength, making it suitable for medical applications.
- PHB's properties can be modified through alloying and compositing for advanced material development.
Purpose of the Study:
- To review the diverse applications of PHB, its alloys, and composites in tissue engineering.
- To highlight fabrication techniques used to create PHB-based scaffolds.
- To discuss how PHB modifications address limitations like hydrophobicity, degradation rate, and brittleness.
Main Methods:
- Scaffold fabrication via polymeric sponge replication.
- Scaffold fabrication via electrospinning.
- Scaffold fabrication via salt leaching.
Main Results:
- PHB alloys and composites demonstrate improved properties for tissue engineering scaffolds.
- Various fabrication methods allow for tailored scaffold structures and functionalities.
- PHB-based materials offer tunable degradation rates and mechanical characteristics.
Conclusions:
- PHB, its alloys, and composites are versatile materials for tissue engineering applications.
- Fabrication methods significantly influence the performance of PHB-based scaffolds.
- Further research into PHB modifications can lead to advanced regenerative medicine solutions.
