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Modified poly(3-hydroxybutyrate)-based scaffolds in tissue engineering applications: A review.

Sanaz Soleymani Eil Bakhtiari1, Saeed Karbasi2, Elahe Bahremandi Toloue2

  • 1Advanced Materials Research Center, Department of Materials Engineering, Najafabad Branch, Islamic Azad University, Najafabad, Iran.

International Journal of Biological Macromolecules
|November 5, 2020
PubMed
Summary

Poly(3-hydroxybutyrate) (PHB), a biocompatible polymer, shows promise in tissue engineering. This review explores PHB alloys and composites fabricated using methods like electrospinning for enhanced scaffold properties.

Keywords:
CompositePoly (3-hydroxybutyrate)ScaffoldTissue engineering

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Area of Science:

  • Biomaterials Science
  • Polymer Science
  • Tissue Engineering

Background:

  • Poly(3-hydroxybutyrate) (PHB) is a notable member of the polyhydroxyalkanoate (PHA) family.
  • PHB offers excellent biocompatibility, non-toxic degradation products, and high mechanical strength, making it suitable for medical applications.
  • PHB's properties can be modified through alloying and compositing for advanced material development.

Purpose of the Study:

  • To review the diverse applications of PHB, its alloys, and composites in tissue engineering.
  • To highlight fabrication techniques used to create PHB-based scaffolds.
  • To discuss how PHB modifications address limitations like hydrophobicity, degradation rate, and brittleness.

Main Methods:

  • Scaffold fabrication via polymeric sponge replication.
  • Scaffold fabrication via electrospinning.
  • Scaffold fabrication via salt leaching.

Main Results:

  • PHB alloys and composites demonstrate improved properties for tissue engineering scaffolds.
  • Various fabrication methods allow for tailored scaffold structures and functionalities.
  • PHB-based materials offer tunable degradation rates and mechanical characteristics.

Conclusions:

  • PHB, its alloys, and composites are versatile materials for tissue engineering applications.
  • Fabrication methods significantly influence the performance of PHB-based scaffolds.
  • Further research into PHB modifications can lead to advanced regenerative medicine solutions.