Succinate Dehydrogenase and Ribonucleic Acid Networks in Cancer and Other Diseases

Area of Science:

• Mitochondrial biology
• Molecular oncology
• RNA biology

Background:

• Succinate dehydrogenase (SDH) links the TCA cycle and ETC, crucial for cellular energy.
• SDH mutations lead to succinate accumulation, driving cancer and other diseases by activating signaling pathways.
• Emerging research highlights the role of RNA networks (non-coding RNAs, RNA editing, modification) in SDH-related pathologies.

Purpose of the Study:

• To review recent advances in understanding RNA networks connected to SDH.
• To discuss the interplay between SDH dysfunction and RNA networks in disease pathogenesis.
• To explore current and emerging therapeutics targeting SDH and its associated RNA networks.

Main Methods:

• Literature review of recent discoveries on SDH and RNA networks.
• Analysis of mechanistic studies on succinate-mediated signaling.
• Survey of pre-clinical and clinical trials for SDH-targeting therapeutics.

Main Results:

• Succinate accumulation due to SDH dysfunction activates hypoxia and other pathways.
• RNA networks, including non-coding RNAs and RNA modifications, are increasingly recognized as key players in SDH-related diseases.
• Several therapeutic strategies targeting SDH and RNA networks are under investigation.

Conclusions:

• A novel model of SDH-RNA network interaction is proposed.
• RNA therapeutics show promise for treating SDH-relevant cancers and other diseases.
• Further research into SDH-RNA interactions could unveil new therapeutic targets.