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Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...

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ACR Appropriateness Criteria® Liver Lesion-Initial Characterization.

, Victoria Chernyak¹, Jeanne M Horowitz²

¹Montefiore Medical Center, Bronx, New York.

Journal of the American College of Radiology : JACR

|November 6, 2020

Summary

This summary is machine-generated.

Incidental liver masses require accurate characterization. This review guides the use of imaging modalities for incidentally detected liver lesions in various clinical scenarios.

Keywords:

AUC Appropriate Use Criteria Appropriateness Criteria Hepatocellular carcinoma Liver lesion Liver mass Liver metastases Liver nodule

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Area of Science:

Radiology
Hepatology
Medical Imaging

Background:

Incidental liver masses are frequently found during imaging for other reasons.
Accurate characterization of these lesions is crucial, especially in patients with existing cancer.
Benign focal liver lesions are common in adults.

Framework:

This document reviews imaging modalities for incidentally detected liver lesions.
It discusses their use within specific clinical scenarios.
Evidence supporting each diagnostic modality is summarized.

Implementation:

The American College of Radiology Appropriateness Criteria provide evidence-based guidelines.
These guidelines are developed by a multidisciplinary panel and annually reviewed.
Methodologies like RAND/UCLA and GRADE are used to assess appropriateness.

Implications:

This review aids clinicians in selecting appropriate imaging for liver lesions.
It addresses situations with limited or conflicting evidence.
Expert opinion supplements evidence when necessary for recommendations.