Evaluation and Management of Patients With Stable Angina: Beyond the Ischemia Paradigm: JACC State-of-the-Art Review
Richard Ferraro1, Jacqueline M Latina1, Abdulhamied Alfaddagh1
1Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Insights
Effective lifestyle changes and medical therapy can prevent adverse events in coronary heart disease. The role of coronary artery revascularization is decreasing, emphasizing the need for improved prevention strategies.
Area of Science:
- Cardiology
- Public Health
Background:
- Coronary heart disease (CHD) is a chronic, systemic condition with significant health care costs.
- Adverse events in CHD can be managed through lifestyle modifications, risk factor control, and medical therapy.
- Prevention and medical treatments are increasingly effective in managing atherosclerotic disease and thrombosis.
Purpose of the Study:
- To review scientific evidence for medical therapy and revascularization in stable coronary heart disease.
- To discuss implications for patient evaluation and public policy regarding stable angina management.
Main Methods:
- Review of scientific evidence.
- Analysis of current treatment paradigms for stable coronary heart disease.
Main Results:
- Medical therapy and lifestyle changes effectively slow CHD progression and reduce thrombotic risks.
- The necessity of coronary artery revascularization is diminishing, now primarily for specific patient subgroups.
- There is a critical need for optimized resource allocation towards prevention strategies.
Conclusions:
- Medical management and prevention are paramount in treating stable coronary heart disease.
- Revascularization is reserved for select patients with severe symptoms or high-risk anatomy.
- Public policy and clinical evaluation should prioritize enhanced prevention efforts for CHD.
Abstract:
Coronary heart disease is a chronic, systemic disease with a wide range of associated symptoms, clinical outcomes, and health care expenditure. Adverse events from coronary heart disease can be mitigated or avoided with lifestyle and risk factor modifications, and medical therapy. These measures are effective in slowing the progression of atherosclerotic disease and in reducing the risk of thrombosis in the setting of plaque disruptions. With increasing effectiveness of prevention and medical therapy, the role of coronary artery revascularization has decreased and is largely confined to subgroups of patients with unacceptable angina, severe left ventricular systolic dysfunction, or high-risk coronary anatomy. There is a compelling need to allocate resources appropriately to improve prevention. Herein, we review the scientific evidence in support of medical therapy and revascularization for the management of patients with stable coronary heart disease and discuss implications for the evaluation of patients with stable angina and public policy.
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