Stage Migration for Upper Tract Urothelial Cell Carcinoma
Asef Aziz1, Syed J Raza1, Facundo Davaro1
1Division of Urology, Department of Surgery, Saint Louis University, St Louis, MO.
Clinical Genitourinary Cancer
|November 6, 2020
Summary
Upper tract urothelial carcinomas (UTUCs) show stage migration toward earlier (stage 0) and later (stage 4) diagnoses. Despite this shift in upper tract urothelial carcinoma staging, overall survival rates remained stable between 2004 and 2011.
Area of Science:
- Urology
- Oncology
- Cancer Research
Background:
- Upper tract urothelial carcinomas (UTUCs) represent 5-10% of all urothelial cancers.
- Increased use of cross-sectional imaging has led to observations of stage migration in various tumors.
Purpose of the Study:
- To analyze trends in the stage at presentation for UTUCs.
- To evaluate the impact of stage migration on overall survival for UTUC patients.
Main Methods:
- Analysis of UTUC cases in the renal pelvis or ureter from 2004 to 2016 using the National Cancer Database.
- Categorization of tumor stage into early (0-1), intermediate (2-3), and late (4) for survival analyses.
- Utilized linear regression and Kaplan-Meier analyses to assess trends and survival outcomes.
Main Results:
- Observed stage migration towards stage 0 and stage 4 disease for both renal pelvic and ureteral UTUCs.
- Significant increase in stage 0 and stage 4 diagnoses, with concurrent decreases in stages 1-3 for renal pelvic UTUCs.
- Significant increases in stage 0 and stage 4 diagnoses for ureteral UTUCs, with reductions in stages 1 and 2.
Conclusions:
- A notable stage migration phenomenon exists for UTUC, shifting diagnoses towards the earliest (stage 0) and most advanced (stage 4) categories.
- Five-year overall survival data for UTUCs from 2004 to 2011 remained consistent across early, intermediate, and late stage groups, indicating stable survival outcomes despite stage migration.
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