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A Novel Stretching Platform for Applications in Cell and Tissue Mechanobiology

A Novel Stretching Platform for Applications in Cell and Tissue Mechanobiology

Published on: June 3, 2014

A versatile biaxial testing platform for soft tissues.

Mingliang Jiang¹, Raghuveer Lalitha Sridhar², Andrew B Robbins²

¹Mechanical Engineering, Hefei University of Technology, Hefei, Anhui, China; Mechanical Engineering, Texas A&M University, College Station, TX, United States of America.

Journal of the Mechanical Behavior of Biomedical Materials

|November 6, 2020

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This study presents a custom biaxial testing system overcoming limitations of commercial devices. The versatile system enhances mechanical analysis of soft materials, including biological tissues.

Area of Science:

Materials Science
Biomedical Engineering
Mechanical Engineering

Background:

Uniaxial testing is standard for soft materials, but biaxial testing offers deeper mechanical insights.
Commercial biaxial testing systems for biological materials have limitations in sample geometry, clamping, load/displacement range, and software control.
Custom-designed systems can address these limitations, enabling broader material characterization.

Purpose of the Study:

To present a novel biaxial testing system design.
To overcome the constraints of commercially available biaxial testing systems.
To offer enhanced capabilities for mechanical analysis of soft and biological materials.

Main Methods:

Design and construction of a custom biaxial testing system.

Keywords:

Biaxial tensile testing Clamping Soft tissue Uniaxial tensile testing

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Development of testing protocols for various mechanical tests.

Proof-of-concept experiments on silicone membranes and rat abdominal skin samples.

Main Results:

The custom system successfully performed uniaxial, biaxial, and double lap shear tests.
The system demonstrated versatility in both displacement and load control modes.
Proof-of-concept experiments validated the system's capabilities on diverse soft materials.

Conclusions:

The developed biaxial testing system provides a more comprehensive mechanical analysis of soft and biological materials.
This custom system surpasses the limitations of typical commercial devices, offering greater flexibility and range.
The design facilitates advanced research in soft material mechanics and biomechanics.