Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Survival Analysis01:21

Cancer Survival Analysis

548
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
548
Tumor Progression02:07

Tumor Progression

7.0K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

World Health Organization classification of tumours of the breast 6th edition 2026.

Histopathology·2026
Same author

DCIS-like invasive carcinoma of the breast with tumour-associated microvasculature mimicking myoepithelium: a diagnostic pitfall.

Histopathology·2025
Same author

Updates on breast biomarkers.

Virchows Archiv : an international journal of pathology·2022
Same author

Nodular fasciitis of the breast: clinicopathologic and molecular characterization with identification of novel USP6 fusion partners.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc·2021

Related Experiment Video

Updated: Dec 2, 2025

Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis
07:32

Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis

Published on: April 12, 2024

1.7K

Prognostic and predictive parameters in breast pathology: a pathologist's primer.

Kimberly H Allison1

  • 1Professor of Pathology, Director of Breast Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA. allisonk@stanford.edu.

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
|November 6, 2020
PubMed
Summary

Pathologists provide crucial prognostic and predictive markers for breast cancer, guiding individualized treatment. Key factors like ER, HER2, and gene-expression panels personalize therapy decisions for better patient outcomes.

More Related Videos

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
07:41

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

Published on: May 17, 2019

9.3K
Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material
11:12

Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material

Published on: August 1, 2018

8.2K

Related Experiment Videos

Last Updated: Dec 2, 2025

Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis
07:32

Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis

Published on: April 12, 2024

1.7K
Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
07:41

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

Published on: May 17, 2019

9.3K
Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material
11:12

Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material

Published on: August 1, 2018

8.2K

Area of Science:

  • Oncology
  • Pathology
  • Genomics

Background:

  • The pathologist's role in breast cancer management has expanded beyond diagnosis.
  • Prognostic and predictive parameters are essential for personalized treatment strategies.

Purpose of the Study:

  • To review the latest prognostic and predictive parameters in breast cancer.
  • To highlight their relevance in pathology reporting and clinical decision-making.

Main Methods:

  • Review of current literature on breast cancer biomarkers.
  • Analysis of established and emerging prognostic and predictive factors.
  • Integration of genomic and histopathologic data.

Main Results:

  • Estrogen Receptor (ER), HER2 status, and traditional parameters (histologic subtype, size, grade) remain vital.
  • Gene-expression panels, like the 21-gene Recurrence Score, predict chemotherapy benefit in ER-positive, HER2-negative disease.
  • Tumor-infiltrating lymphocytes (TILs) and response to neoadjuvant therapy are key in ER-negative subtypes.
  • Germline BRCA, PIK3CA, and PD-L1 status guide treatment in metastatic breast cancer.

Conclusions:

  • Pathology reporting increasingly incorporates advanced markers for tailored breast cancer treatment.
  • These parameters enable precise patient stratification and selection for targeted therapies.
  • The evolution of pathology supports individualized care pathways in all stages of breast cancer.