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Pancreas transplantation.

D E Sutherland1

  • 1Department of Surgery, University of Minnesota Hospitals, Minneapolis 55455.

Diabetes/Metabolism Reviews
|October 1, 1987
PubMed
Summary
This summary is machine-generated.

Pancreas transplantation success rates are rising, benefiting diabetic patients and expanding to those without kidney failure. Early detection of rejection and improved diabetes complications are key outcomes.

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Area of Science:

  • Transplantation immunology
  • Endocrinology
  • Nephrology

Background:

  • Pancreas transplantation is increasingly successful.
  • Most recipients have diabetes and kidney transplants, but use in nonuremic patients is growing.
  • Bladder drainage aids exocrine function assessment and rejection monitoring.

Purpose of the Study:

  • To review the current status and outcomes of pancreas transplantation.
  • To highlight advancements in immunosuppression and surgical techniques.
  • To discuss the impact of successful pancreas transplants on diabetes complications.

Main Methods:

  • Review of current pancreas transplant literature.
  • Analysis of graft survival rates and immunosuppressive strategies.

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  • Assessment of diagnostic methods for rejection and exocrine function.

    • Main Results:

    • Increased pancreas transplant volume and success rates.
    • Improved graft survival associated with cyclosporine-based immunosuppression.
    • Bladder drainage facilitates early diagnosis and treatment of rejection.

    Conclusions:

    • Pancreas transplantation is a viable option for managing diabetes, even in nonuremic patients.
    • Effective immunosuppression and monitoring are crucial for graft success.
    • Successful transplantation may favorably impact diabetes-related complications if performed early.