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Phthalic Acid Ester-Binding DNA Aptamer Selection, Characterization, and Application to an Electrochemical Aptasensor

Phthalic Acid Ester-Binding DNA Aptamer Selection, Characterization, and Application to an Electrochemical Aptasensor

Published on: March 21, 2018

Recent Developments in Aptasensors for Diagnostic Applications.

Ling Sum Liu¹, Fei Wang¹, Yonghe Ge¹

¹Department of Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR, China.

ACS Applied Materials & Interfaces

|November 6, 2020

Summary

Aptamer-based biosensors offer superior alternatives to antibodies for detecting disease biomarkers. These advanced aptasensors utilize various nanomaterials and signal transduction methods for sensitive clinical diagnostics and molecular imaging.

Keywords:

aptamers aptasensors detection diagnosis recognition

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Area of Science:

Biomedical Engineering
Molecular Diagnostics
Nanotechnology

Background:

Aptamers are highly specific molecular probes for disease biomarker recognition.
Aptamer-based biosensors are increasingly important for clinical diagnostics.
Functional nanomaterials enhance aptasensor sensitivity and detection limits.

Purpose of the Study:

Highlight aptamers as advantageous alternatives to antibodies for high-throughput screening.
Describe aptamer-target binding configurations and recognition modes.
Explain various signal transduction strategies for aptasensor design.

Main Methods:

Review of aptamer-based biosensor design strategies.
Analysis of aptamer-target pairing configurations (single- and dual-site binding).
Explanation of optical, electrical, mechanical, and mass-sensitive signal transduction methods.

Main Results:

Aptamers offer advantages over antibodies in biosensor applications.
Diverse aptamer-target binding and signal transduction strategies are detailed.
Recent progress in aptasensor development for clinical diagnosis is summarized.

Conclusions:

Aptasensors show significant promise for clinical diagnosis and in vivo molecular imaging.
Further advancements and challenges in aptasensor technology are discussed.
Aptamers are versatile tools for developing next-generation diagnostic platforms.