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Published on: January 12, 2020
Toxicological alert: Exposure to glycidyl methacrylate and cancer risk
Bruno Jose Dumêt Fernandes1, Ricardo David Couto2
1Clinical Toxicology Laboratory, Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, 495454Federal University of Bahia/UFBA, Salvador, Bahia, Brazil.
Abstract:
Glycidyl methacrylate (GMA; CAS no. 106-91-2) is a chemical monomer used in the manufacture of dental resins, can coatings and polymers. GMA has demonstrated toxicity to the ocular, digestive, respiratory and dermal systems. Human exposure occurs mainly in the workplace, but it can also happen through food. Although there were no available data on carcinogenicity of GMA, carcinogenic potential in the nasal cavity is highly expected. Further studies are needed to assess GMA exposure in humans. This study provides an alert of GMA human exposure and its genotoxic and carcinogenic potential.
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