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Author Spotlight: Innovative Techniques for ROS Detection and Implications for Platelet Research
06:35

Author Spotlight: Innovative Techniques for ROS Detection and Implications for Platelet Research

Published on: March 29, 2024

953

Serotonin: a platelet hormone modulating cardiovascular disease

Marina Rieder1,2, Nadine Gauchel3,4, Christoph Bode1,2

  • 1Department of Cardiology and Angiology I, Faculty of Medicine, Heart Center Freiburg University, University of Freiburg, Hugstetter Strasse 55, 79106, Freiburg, Germany.

Journal of Thrombosis and Thrombolysis
|November 6, 2020
PubMed

Insights

Serotonin (5-HT) impacts both cardiovascular disease and depression. This review summarizes 5-HT

Area of Science:

  • Neuroscience
  • Cardiology
  • Psychiatry

Background:

  • Cardiovascular diseases and depression are major global health concerns.
  • A strong link exists, with depression being a risk factor for cardiovascular disease and vice versa.
  • Serotonin (5-HT) plays a role in the pathology of both conditions.

Purpose of the Study:

  • To review novel cardiovascular functions of serotonin (5-HT).
  • To consolidate existing research on 5-HT's role in the cardiovascular system.
  • To identify areas needing further investigation for targeted therapies.

Main Methods:

  • Literature review of clinical and experimental data.
  • Synthesis of existing research on serotonin's cardiovascular effects.
  • Analysis of conflicting data regarding 5-HT's role.

Main Results:

  • Serotonin (5-HT) exhibits diverse functions within the cardiovascular system.
  • Existing data on 5-HT's cardiovascular impact is sometimes contradictory.
  • Novel cardiovascular roles of 5-HT have been recently identified.

Conclusions:

  • Serotonin (5-HT) is a key molecule implicated in both cardiovascular disease and depression.
  • Further research is essential to clarify the specific tissue effects of 5-HT.
  • Understanding these effects will enable the development of targeted pharmacological treatments.

Keywords:
5-hydroxytryptaminCardiovascular diseasePlateletsSerotonin

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