Physiological balance of haemostasis and bleeding
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1Department of Medicine, University of Rochester School of Medicine and Dentistry.
A complex series of cellular and molecular interactions is involved in fibrinolysis, which is controlled by mechanisms that provide for localised activation or suppression without systemic effects, thereby providing an orderly process of haemostasis, healing and response to thrombotic injury. Excessive or deficient fibrinolysis may be congenital or acquired, the latter including iatrogenic interventions, and such variations in the balance may result in accelerated recovery from disease or a thrombotic or haemorrhagic complication.
A complex series of cellular and molecular interactions is involved in fibrinolysis, which is controlled by mechanisms that provide for localised activation or suppression without systemic effects, thereby providing an orderly process of haemostasis, healing and response to thrombotic injury. Excessive or deficient fibrinolysis may be congenital or acquired, the latter including iatrogenic interventions, and such variations in the balance may result in accelerated recovery from disease or a thrombotic or haemorrhagic complication.